FOR RESEARCH SCIENTIFIC STUDIES ONLY- NOT FOR HUMAN/ANIMAL CONSUMPTION/USE
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SLU-PP-332 2MG is a synthetic small-molecule research compound intended for laboratory investigation of estrogen-related receptor signaling, mitochondrial metabolism, oxidative phosphorylation, fatty acid utilization, skeletal-muscle biology, and exercise-responsive molecular pathways.
Unlike peptide-based research materials, this compound belongs to the small-molecule research category. It has attracted scientific interest because of its activity toward the estrogen-related receptor (ERR) family, a group of nuclear receptors involved in regulating genes associated with cellular energy metabolism.
The ERR family includes ERRα, ERRβ, and ERRγ. These receptors have been investigated extensively in connection with mitochondrial activity, oxidative metabolism, fatty acid utilization, skeletal-muscle function, and cellular energy regulation.
Published research has characterized SLU-PP-332 as a pan-ERR agonist, with particularly strong activity reported toward ERRα. Experimental studies have investigated its effects on mitochondrial respiration, skeletal-muscle metabolism, exercise-responsive transcription, and metabolic pathways.
This research material is therefore relevant to laboratories studying nuclear receptor pharmacology, mitochondrial biology, metabolic signaling, exercise physiology, and small-molecule structure-activity relationships.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
SLU-PP-332 is a synthetic chemical compound developed as a research tool for investigating estrogen-related receptors.
Although these receptors contain the word "estrogen" in their name, estrogen-related receptors are different from classical estrogen receptors. They belong to the nuclear receptor superfamily and function primarily as transcriptional regulators.
Researchers have connected ERR signaling with several important cellular processes, including:
The compound is particularly interesting because it provides researchers with a pharmacological approach to investigate ERR signaling in experimental systems.
The original scientific characterization reported activity across the ERR receptor family and examined downstream metabolic and transcriptional effects.
Estrogen-related receptors are orphan nuclear receptors that regulate transcription of genes involved in energy metabolism.
The three primary members are:
These receptors have different biological distributions and functions, but collectively they are strongly associated with cellular energy regulation.
ERRα, for example, has been extensively studied in relation to mitochondrial oxidative metabolism and skeletal-muscle function.
ERRγ has also been associated with metabolic regulation in several tissues.
ERRβ has been investigated in developmental and metabolic contexts.
Because the three receptor subtypes can have overlapping but distinct biological roles, compounds capable of interacting with multiple ERRs are valuable tools for comparative research.
Nuclear receptors function by regulating gene transcription.
In simplified terms, receptor activation can influence the expression of genes involved in cellular metabolism and energy production.
For researchers, this makes ERR signaling particularly interesting because it connects receptor pharmacology with downstream metabolic processes.
Experimental research involving this compound can therefore examine:
These relationships make the compound useful as a chemical tool for investigating the connection between nuclear receptor signaling and cellular metabolism.
ERRα is one of the most extensively investigated receptors within this family.
It has been associated with transcriptional programs regulating mitochondrial activity and oxidative metabolism.
Mitochondria are responsible for much of the ATP production required by cells. Tissues with high energy demands, such as skeletal muscle and cardiac muscle, have particularly high mitochondrial requirements.
Researchers studying ERRα can investigate:
The original study of SLU-PP-332 reported increased mitochondrial respiration in skeletal-muscle cells and examined ERRα-dependent exercise-related pathways.
This provides a scientific basis for using the compound in controlled mitochondrial and metabolic research.
Mitochondrial metabolism is a central area of modern cell biology.
Cells use mitochondria to convert nutrients into usable chemical energy. This involves several interconnected processes, including the citric acid cycle, electron transport, and oxidative phosphorylation.
Researchers investigating mitochondrial function may measure:
ERR-related signaling provides one molecular route through which these processes can be studied.
For this reason, SLU-PP-332 is relevant to research programs focused on mitochondrial biology and metabolic signaling.
Oxidative phosphorylation is the process through which mitochondria generate ATP using energy derived from metabolic substrates.
It involves the electron transport chain and ATP synthase and depends heavily on mitochondrial integrity.
Researchers can use ERR pathway activation as a model for investigating changes in genes and pathways involved in oxidative metabolism.
Potential research endpoints include:
This makes the compound relevant to laboratories studying the molecular regulation of cellular energy production.
Fatty acids are an important energy substrate, particularly in tissues with high oxidative capacity.
The process of breaking down fatty acids through mitochondrial β-oxidation generates substrates that can subsequently contribute to ATP production.
ERR signaling has been associated with transcriptional regulation of genes involved in oxidative metabolism and fatty acid utilization.
Experimental studies have investigated this compound in relation to increased fatty acid oxidation and metabolic changes in animal models.
This research area may include:
Skeletal muscle is one of the body's most metabolically active tissues.
Muscle cells require substantial amounts of ATP during physical activity, and mitochondrial capacity is an important component of their oxidative metabolism.
Scientific research involving SLU-PP-332 has examined skeletal-muscle responses associated with ERR activation.
The original preclinical study reported changes in oxidative muscle fibers and investigated exercise capacity in mice.
These observations have made the compound useful as a research tool for studying:
Importantly, findings from animal studies should not be interpreted as evidence of equivalent effects in humans.
Exercise causes widespread changes in cellular metabolism and gene expression.
Skeletal muscle responds to exercise by altering pathways associated with:
Researchers have identified ERR-dependent transcriptional programs among the pathways associated with these responses.
The original study described SLU-PP-332 as a tool for inducing an ERRα-dependent exercise-related transcriptional program in experimental models.
This makes it valuable for investigating the molecular mechanisms behind exercise-responsive metabolism.
It is important, however, to distinguish experimental pathway activation from the physiological effects of actual exercise.
The compound has also been studied in experimental metabolic models.
Research published in the Journal of Pharmacology and Experimental Therapeutics examined its effects in mouse models associated with obesity and metabolic syndrome. Researchers reported changes involving energy expenditure, fatty acid oxidation, and metabolic parameters.
This provides a foundation for laboratory studies investigating:
These studies remain preclinical and should be presented accordingly.
Nuclear receptors are an important family of transcription-regulating proteins.
Researchers use small molecules that interact with nuclear receptors to investigate:
ERRs are particularly interesting because of their connection to cellular metabolism.
The availability of a synthetic ERR agonist allows researchers to study receptor activation under controlled experimental conditions.
Changes in gene expression are one of the major downstream consequences investigated in ERR research.
Laboratories can examine transcriptional responses using techniques such as:
Researchers can compare treated and control experimental systems to determine which metabolic pathways respond to ERR activation.
This can help identify relationships between receptor activity and mitochondrial or metabolic gene networks.
Structure-activity relationship, or SAR, research examines how chemical modifications affect biological activity.
This is an important field in medicinal chemistry and pharmacology.
Researchers may modify a small-molecule scaffold and compare:
Recent research has continued to examine chemical modifications of the SLU-PP-332 scaffold and their effects on ERRα and ERRγ activity.
This makes the compound relevant as a reference molecule for laboratories performing ERR agonist discovery and optimization research.
Analytical characterization is an important component of small-molecule research.
Laboratories may use analytical techniques to confirm:
Common analytical approaches include:
Recent analytical research has specifically investigated the metabolism and transformation products of SLU-PP-332 using high-resolution mass spectrometry.
Understanding how a small molecule changes in biological systems is an important part of analytical pharmacology.
Researchers can investigate:
Recent work has identified multiple transformation products associated with experimental metabolism of SLU-PP-332.
This type of research is particularly useful for analytical laboratories studying small-molecule metabolism.
This research material may be relevant to laboratories investigating:
Study ERRα, ERRβ, and ERRγ signaling.
Investigate mitochondrial respiration and oxidative metabolism.
Study cellular energy metabolism and substrate utilization.
Investigate oxidative muscle metabolism and exercise-responsive pathways.
Study ligand-receptor interactions and transcriptional regulation.
Examine metabolic pathways involved in lipid utilization.
Analyze transcriptional responses associated with ERR activation.
Characterize identity, purity, metabolites, and degradation products.
Compare chemical analogues and receptor activity.
For laboratory research, appropriate characterization and documentation are essential.
Researchers should review the available Certificate of Analysis (COA) for information such as:
The batch-specific documentation should be considered the primary reference for the material supplied.
Store the research material according to the manufacturer's current product-specific storage recommendations.
Laboratories should consider:
Researchers should use appropriate laboratory procedures when handling synthetic small molecules.
For additional educational information, visitors can explore the LabRat Peptides Research Hub and the Research Collection.
This material is intended strictly for qualified laboratory research.
Researchers should follow appropriate institutional procedures covering:
Published studies may describe specific experimental concentrations, administration methods, or animal models. Such information should not be interpreted as directions for human use.
For visitors who want to explore the underlying scientific literature, authoritative resources include:
Original SLU-PP-332 ERR Research – PubMed
The original study investigated ERR activation, mitochondrial respiration, skeletal muscle, exercise-responsive transcription, and exercise capacity in experimental models.
This research examined metabolic effects associated with ERR activation in experimental mouse models.
SLU-PP-332 Metabolite Research – PubMed
This recent analytical study investigated metabolic transformation products using high-resolution mass spectrometry.
Structure-Activity Research – PubMed
This research examined chemical modifications and structure-activity relationships associated with the compound's ERR activity.
These links are also useful for establishing authoritative outbound references on the product page.
It is a synthetic small-molecule research compound used for laboratory investigation of estrogen-related receptor signaling and associated metabolic pathways.
No. It is a small molecule, not a peptide.
Research has characterized it as a pan-ERR agonist capable of activating ERRα, ERRβ, and ERRγ, with particularly strong activity toward ERRα.
ERRα is an orphan nuclear receptor involved in transcriptional regulation of genes associated with energy metabolism and mitochondrial function.
Research areas include mitochondrial biology, metabolic signaling, skeletal-muscle metabolism, nuclear receptor pharmacology, fatty acid oxidation, gene expression, and analytical chemistry.
Yes. Published preclinical studies have investigated its effects in mouse models involving skeletal muscle, exercise responses, and metabolic pathways.
It should be described as an experimental research compound, not as an approved human medicine.
Researchers may use HPLC, LC-MS, LC-MS/MS, and high-resolution mass spectrometry for characterization and metabolite research.
ERR signaling is closely associated with genes involved in mitochondrial oxidative metabolism, making receptor activation an interesting experimental approach for studying cellular energy pathways.
Researchers can review peer-reviewed publications through databases such as PubMed, including the studies linked above.
Researchers interested in metabolic and cellular-energy research can explore the LabRat Peptides Research Collection.
Additional educational material is available through the LabRat Peptides Research Hub.
Where appropriate, you can also internally link this page to related products such as AICAR and SS-31, as well as your Metabolic Research or Research Compounds category pages.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
SLU-PP-332 2MG is supplied as research material for scientific investigation and laboratory research. The information presented here is intended for educational and scientific purposes and does not constitute medical advice.
Experimental findings from cell or animal studies should not be interpreted as evidence of human therapeutic efficacy or safety.
Researchers are responsible for complying with all applicable laws, regulations, institutional requirements, laboratory procedures, and approved research protocols.
| Sequence | Available on COA |
| Appearance | White Lyophilized Powder |
| Mol. Weight | 1419.6 g/mol |
| Purity | 99.2% |
| Storage | -20°C or below |
| SKU | SLU-PP-332 |
All peptides and research chemicals sold on this site are intended exclusively for in-vitro laboratory research. They are not approved for human consumption, medical treatment, veterinary use, or any in-vivo application.
