FOR RESEARCH SCIENTIFIC STUDIES ONLY- NOT FOR HUMAN/ANIMAL CONSUMPTION/USE
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FOXO4-DRI 10MG is a synthetic peptide research material investigated in laboratory studies involving cellular senescence, FOXO4-p53 signaling, apoptosis, aging biology, molecular interactions, and senescent-cell research.
FOXO4-DRI is a D-retro-inverso peptide designed to investigate the interaction between the FOXO4 protein and the tumor-suppressor protein p53. Experimental research has shown that the peptide can interfere with the FOXO4-p53 interaction, providing researchers with a molecular tool for studying mechanisms involved in the persistence and survival of senescent cells. PubMed Central (PMC)
Cellular senescence is a complex biological state characterized by stable changes in cell-cycle activity and cellular function. The FOXO4-p53 pathway has become an important subject of research because it may contribute to the survival of certain senescent cells.
The 10MG presentation provides a defined quantity of research material for appropriately designed laboratory experiments.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
FOXO4-DRI is a synthetic peptide developed to study the interaction between FOXO4 and p53.
FOXO4 belongs to the forkhead box O (FOXO) family of transcription factors. These proteins participate in numerous cellular processes, including:
FOXO4 has attracted particular interest in senescence research because of its interaction with p53.
Research has shown that FOXO4-DRI can compete with FOXO4 for interaction with p53, making the peptide useful as an experimental tool for investigating this protein-protein interaction. PubMed
The FOXO4-p53 axis is a major area of investigation in cellular senescence research.
p53 is a well-characterized tumor-suppressor protein involved in:
FOXO4 can interact with p53 under certain cellular conditions.
Experimental research has investigated whether disrupting this interaction can alter the survival characteristics of senescent cells.
Structural studies published in 2025 further characterized the interaction between FOXO4-DRI and the p53 transactivation domain, providing additional molecular information about how the peptide interacts with its target. PubMed
Cellular senescence describes a stable cellular state associated with changes in proliferation, metabolism, gene expression, and secretory activity.
Senescent-cell research examines numerous biological markers, including:
The accumulation of senescent cells is an active area of aging and cell-biology research.
FOXO4-DRI provides researchers with a tool for studying molecular mechanisms associated with senescent-cell survival and apoptosis.
A senolytic refers broadly to an experimental approach intended to selectively eliminate senescent cells.
FOXO4-DRI has been investigated as a senolytic peptide in preclinical research.
Earlier experimental work found that the peptide could interfere with FOXO4-p53 binding and promote apoptosis in senescent cells. PubMed Central (PMC)
This research has made FOXO4-DRI relevant to studies investigating:
Importantly, these findings are primarily from experimental and preclinical models and should not be interpreted as established human therapeutic outcomes.
Apoptosis is a regulated form of programmed cell death.
Researchers investigating apoptosis commonly measure:
Experimental research has reported that disrupting the FOXO4-p53 interaction can promote apoptosis in senescent cells under certain experimental conditions. PubMed
These observations provide opportunities for researchers to investigate the molecular relationship between senescence and programmed cell death.
p53 is one of the most extensively studied proteins in molecular biology.
It plays important roles in responding to cellular stress and DNA damage.
Researchers can examine:
Recent structural research found that FOXO4-DRI interacts with the p53 transactivation domain and provided additional information about the molecular basis of this interaction. PubMed
The location of signaling proteins within the cell can influence their function.
Research involving FOXO4 and p53 may therefore examine:
Experimental studies have reported that disruption of FOXO4-p53 interactions can influence p53 localization in senescent-cell models. PubMed Central (PMC)
Techniques such as immunofluorescence and cellular fractionation can be used to study these changes.
Cellular aging is influenced by numerous interacting mechanisms.
Important research areas include:
The FOXO4-p53 pathway represents one molecular mechanism being investigated within this broader field.
FOXO4-DRI can therefore be used as an experimental tool in studies examining relationships between protein interactions and cellular aging.
FOXO transcription factors are closely associated with cellular stress responses.
Research into FOXO4 includes investigation of:
A recent 2026 review examined FOXO4 as a redox-sensitive regulator and discussed the relationship between FOXO4, oxidative stress, cellular senescence, and p53 signaling. The review also emphasized that some proposed FOXO4 antioxidant functions remain incompletely established. PubMed
This distinction is important when interpreting experimental findings.
Recent research has investigated FOXO4-DRI in models of endothelial-cell senescence.
A 2026 study reported that the peptide disrupted FOXO4-p53 interaction in experimental endothelial models and investigated downstream changes involving p53, BAX, BCL-2, and caspase-3. The study also used aged mouse models to investigate vascular effects. PubMed
These findings provide a current research direction for scientists studying:
Because these observations come from experimental models, further research is required to determine their broader biological significance.
FOXO4-DRI has also been investigated in experimental fibroblast models.
A 2025 study examining keloid-associated fibroblasts reported that the peptide promoted apoptosis in senescent fibroblast models and investigated changes involving phosphorylated p53 and nuclear localization. PubMed
This type of research can help scientists investigate whether the FOXO4-p53 interaction behaves differently across specific cell types and senescence models.
Cellular senescence is also relevant to cancer biology.
Senescent cancer cells and therapy-induced senescence are active areas of investigation because senescent cells can display altered signaling and secretory characteristics.
Researchers have investigated peptides targeting FOXO4-p53 interactions as experimental approaches for studying senescent cancer cells. PubMed
This does not establish FOXO4-DRI as a cancer treatment. Instead, it highlights its value as an experimental tool for investigating molecular mechanisms associated with senescent-cell survival.
One of the most interesting characteristics of this research peptide is its use in studying protein-protein interactions.
FOXO4-DRI research can investigate:
Nuclear magnetic resonance (NMR) studies have provided structural information about FOXO4-DRI interaction with the p53 transactivation domain. PubMed
This makes the compound relevant to structural biology and molecular pharmacology research.
Laboratories investigating this peptide may use several analytical approaches.
Can be used to investigate proteins such as p53, FOXO4, BAX, BCL-2, and cleaved caspases.
Can help visualize protein localization and nuclear/cytoplasmic distribution.
Can be used to investigate protein-protein interactions.
Can measure changes in gene expression associated with senescence and apoptosis.
Can assess cellular viability, apoptosis markers, and cell-cycle characteristics.
Can provide structural information about peptide-protein interactions.
Researchers studying cellular senescence may evaluate several independent markers rather than relying on a single measurement.
Potential endpoints include:
Using multiple markers can provide stronger evidence that cells have entered a senescent state.
Research peptides should be appropriately characterized before experimental use.
Potential analytical methods include:
Testing may provide information about:
Researchers should review available batch-specific analytical documentation before beginning experiments.
A Certificate of Analysis (COA) can provide important batch-specific information.
Depending on the quality-control program, a COA may include:
Maintaining batch records supports experimental traceability and reproducibility.
A COA describes analytical characteristics of a particular batch and should not be interpreted as evidence of human efficacy or safety.
Research peptides should be handled and stored according to the manufacturer's current product-specific documentation.
Potential factors affecting peptide integrity include:
Laboratory personnel should minimize unnecessary exposure to conditions that may compromise sample integrity.
This research material should be handled by appropriately trained laboratory personnel.
Standard laboratory practices may include:
Researchers should review the applicable SDS and product documentation before starting experimental work.
Potential areas of investigation include:
Study of senescent-cell survival and molecular characteristics.
Investigation of experimental mechanisms for targeting senescent cells.
Study of protein-protein interactions and signaling.
Investigation of programmed cell death pathways.
Research into cellular mechanisms associated with aging.
Study of peptide-mediated protein interactions.
Investigation of peptide-protein binding.
Research into senescence-associated mechanisms in cancer models.
Researchers should consider:
Experimental Controls
Use appropriate negative and positive controls to distinguish specific effects from nonspecific cellular responses.
Cellular Model
Different cell types can have substantially different senescence pathways and responses.
Senescence Validation
Multiple senescence markers should ideally be used to validate the experimental model.
Protein Interaction Measurements
Co-immunoprecipitation, imaging, or structural techniques can provide complementary information.
Apoptosis Measurements
Multiple endpoints can help distinguish apoptosis from general cytotoxicity.
Replication
Independent experimental replicates improve reproducibility.
A laboratory study may follow:
Material Selection → Analytical Verification → Senescence Model → Experimental Exposure → Protein/Cellular Analysis → Apoptosis Assessment → Molecular Analysis → Data Interpretation
The precise workflow should be determined by the validated laboratory protocol and research objective.
FOXO4-DRI is a synthetic D-retro-inverso peptide designed to investigate the interaction between FOXO4 and p53.
It describes a molecular interaction between FOXO4 and the tumor-suppressor protein p53 that has been investigated in relation to senescent-cell survival.
A senolytic peptide is an experimental peptide investigated for its ability to preferentially affect senescent cells.
Research includes cellular senescence, apoptosis, aging biology, protein-protein interactions, p53 signaling, molecular biology, and experimental senolytic research.
Researchers may use techniques such as co-immunoprecipitation, NMR spectroscopy, Western blotting, and immunofluorescence.
No. This product is intended for research use only and is not intended for human or veterinary use.
For further scientific research, use authoritative resources such as:
National Center for Biotechnology Information
Recent peer-reviewed research provides useful information about the structural basis of the FOXO4-p53 interaction and ongoing experimental investigations of FOXO4-DRI. PubMed
Use contextual internal links throughout the page.
Example:
Researchers investigating related research peptides can explore the broader LabRat Peptides collection.
Another example:
Additional educational resources covering peptide science, cellular research, and laboratory methodologies are available through the LabRat Peptides Research Hub.
Relevant internal categories to link naturally where appropriate:
Researchers studying cellular aging, senescence, molecular signaling, and peptide research can explore the LabRat Peptides Research Collection.
For additional educational information covering peptide science, molecular biology, laboratory methodologies, and analytical testing, visit the LabRat Peptides Research Hub.
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
FOXO4-DRI 10MG is presented as research material for controlled scientific investigation. The information provided is intended for educational and research purposes only and does not constitute medical advice, treatment recommendations, dosing instructions, or instructions for human or veterinary administration.
Published findings concerning this peptide are primarily derived from experimental and preclinical research. Results observed in cell or animal models should not automatically be interpreted as evidence of human therapeutic efficacy or safety. Recent reviews specifically note that FOXO4-DRI remains preclinical and that additional pharmacokinetic, delivery, toxicology, and tissue-specific research is needed. PubMed
Researchers are responsible for complying with applicable laws, institutional requirements, laboratory safety procedures, manufacturer documentation, and approved research protocols.
| Sequence | Available on COA |
| Appearance | White Lyophilized Powder |
| Mol. Weight | 1419.6 g/mol |
| Purity | 99.2% |
| Storage | -20°C or below |
All peptides and research chemicals sold on this site are intended exclusively for in-vitro laboratory research. They are not approved for human consumption, medical treatment, veterinary use, or any in-vivo application.
